The following is the schedule for the conference, current as of 29 October. 2001. All activities will be held on the Caltech campus.

Sunday, November 4, 2001 (Location: Beckman Institute)
Tutorials (two parallel tracks, see Tutorials page for detailed schedule):
  • Modeling and Simulation with the Simulation Environment, ProMoT/DIVA - M. Ginkel and A. Kremling
  • Analysis of Sequence and Expression Data in the Context of Biological Interactions - Jeff Blanchard
  • Genetic Network Analysis: From the Bench to Computers and Back - Z. Szallasi
  • Introduction to Modeling & SBML - H. Sauro, A. Finney, M. Hucka, H. Bolouri
  • Using the Systems Biology Workbench - A. Finney, M. Hucka, H. Sauro, H. Bolouri
  • DNA Microarrays, DNA Structure, and Gene Expression - Pierre Baldi
  • The Virtual Cell Software Environment - I.I. Moraru, J.C. Schaff, J.M. Wagner, D. Lucio
  • An Introduction to CellML for Modelling Cellular and Subcellular Processes - A. Cuellar, F. Livingston, M. Natarajan, A. Muzikant, P. Nielsen
Monday, November 5, 2001 (Location: Ramo Auditorium)
08:30 - 08:45 Welcome to the First Day of ICSB2001, the
Second International Conference on Systems Biology
08:45 - 09:00 Opening Remarks: Hiroaki Kitano (The Systems Biology Institute)
09:00 - 10:00 Keynote Speech I: Alfred Gilman (UT Southwestern, AFCS)
10:00 - 10:20 Coffee/Tea Break
Session I: Modeling Signal Transduction
10:20 - 10:30 Overview of Session: Melvin Simon (Caltech, Biology)
10:30 - 11:05 Uri Alon (Weizmann Institute)
Reverse-engineering the gene regulation network of E. coli
11:05 - 11:40 Dennis Bray (Cambridge University)
Modeling molecular events in a small volume of living cytoplasm
11:40 - 12:15 Peter Devreotes (Johns Hopkins University)
Mechanisns of directional sensing in eucaryotic cells
12:15 - 13:45 Lunch
Session II: Software and Theory in Systems Biology
13:45 - 13:50 Overview of Session: John Doyle (Caltech, EAS)
13:50 - 14:25 Joel Stiles (Pittsburgh Supercomputing Center)
Monte Carlo simulation of realistic cellular microphysiology
14:25 - 15:00 Hiroaki Kitano (The Systems Biology Institute)
SBW/SBML: a software platform and standard for systems biology
15:00 - 15:35 Shoshana J. Wodak (Universite Libre de Bruxelles)
Representing and analyzing biological function with aMAZE, a database of molecular interactions and processes
15:35 - 15:50 Coffee/Tea Break
15:50 - 16:25 Jan-Hendrik Hofmeyr (Stellenbosch University)
Metabolic control analysis: a tool for understanding cellular behaviour, control and regulation
16:25 - 17:00 Michael Savageau (University of Michigan)
Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation within Biochemical Systems Theory
17:00 - 19:30 Poster Session I (Beckman Institute Courtyard)
18:00 - 19:30 Social Gathering (Beckman Institute Courtyard)
Tuesday, November 6, 2001 (Location: Ramo Auditorium)
08:45 - 09:00 Welcome & Announcements for the Second Day
09:00 - 10:00 Keynote Speech II: David Botstein (Stanford University)
Extracting biological information from genome-wide gene expression studies
10:00 - 10:20 Coffee/Tea Break
Session III: Experimental Technologies for Systems Biology
10:20 - 10:30 Overview of Session: Stephen R. Quake (Caltech, EAS)
10:30 - 11:05 Rudy Aebersold (Institute for Systems Biology)
Quantitative proteome analysis: new technology and applications
11:05 - 11:40 David Lockhart (Aventa Biosciences)
Quantitative gene expression profiling in the brain
11:40 - 12:15 Tobias Meyer (Stanford University)
Dynamic properties of cellular signaling networks
12:15 - 13:50 Lunch
Session IV: Modeling Cellular Physiology
13:50 - 14:00 Overview of Session: Ray Deschaies (Caltech, Biology)
14:00 - 14:35

John Tyson (Virginia Tech)
Modeling cell cycle controls: an example of the "last step" of computational molecular biology

14:35 - 15:10 Lucy Shapiro (Stanford University)
A systems engineering approach to the bacterial cell cycle: defining the genetic circuitry
15:10 - 15:30 Coffee/Tea Break
15:30 - 16:05 Douglas Lauffenburger (MIT)
Receptor, ligand, and signaling pathway dynamics in the Epidermal Growth Factor system
16:05 - 16:40 Hans Westerhoff (Vrije University Amsterdam)
Understanding what we already know about the living cell: cellular bioinformatics, computational biochemistry, and the Silicon Cell
16:45 - 18:45 Poster Session II (Beckman Institute Courtyard)
19:00 - 22:00 Banquet (Athenaeum)
Welcome & Introduction by Caltech President David Baltimore
Dinner Speaker: Marvin Cassman (Director, National Institute of General Medical Sciences, National Institutes of Health)

Wednesday, November 7, 2001
08:45 - 09:00 Welcome & Announcements for the Final Day
09:00 - 10:00 Keynote Speech III: Adam Arkin (Lawrence Berkeley Laboratories)
Network bioinformatics: from effect detection to comparative regulation
Session V: Genomics and Systems Biology
10:00 - 10:10 Overview of Session: Barbara Wold (Caltech, Biology)
10:10 - 10:45 David Eisenberg (UCLA)
Protein interactions
10:45 - 11:00 Coffee/Tea Break
11:00 - 11:35 Eric Davidson (Caltech, Biology)
Towards a DNA sequence-based cis-regulatory network model for a major developmental specification process in the sea urchin embryo
11:35 - 12:10 Andrew Murray (Harvard University)
Experimental evolution in yeast: a progress report
12:10 - 12:45 Leroy Hood (Institute for Systems Biology)
Genomics, proteomics, and systems biology
12:45 - 14:25 Lunch
Session VI: Fresh Perspectives in Systems Biology
14:25 - 14:30 Overview of Session: Eric Mjolsness (JPL)
14:30 - 14:55 Birgit Schoeberl (MIT)
A mathematical vision of TNF receptor interaction
14:55 - 15:20 Pablo Iglesias (Johns Hopkins)
Spatial sensing of chemotactic gradients: a reaction-diffusion model
15:20 - 15:45 Joerg Stelling (Max Planck Institute for Dynamics of Complex Technical Systems)
Robustness vs. identifiability of regulatory modules?
15:45 - 16:00 Coffee/Tea Break
16:00 - 16:25 David Wild (Keck Graduate Institute)
Modeling biological responses using gene expression profiling and linear dynamical systems
16:25 - 16:50 Sarah Teichmann (MRC Laboratory of Molecular Biology)
Comparison of the small molecule metabolic pathways in Escherichia coli and Saccharomyces cerevisiae: nonortho-logous displacements, gene fusions and protein interactions
16:50 - 17:15 Eric Mjolsness (JPL)
Developmental simulations with Cellerator
17:15 - 17:30 Closing Remarks
Hiroaki Kitano (The Systems Biology Institute)

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